UNUSUAL PRESENTATION OF JAK2-NEGATIVE POLYCYTHEMIA

Absence of CALR mutations in JAK2-negative polycythemia.

Presence of calreticulin mutations in JAK2-negative polycythemia vera.

Calreticulin (CALR) mutations have been reported in Janus kinase 2 (JAK2)- and myeloproliferative leukemia (MPL)-negative essential thrombocythemia and primary myelofibrosis. In contrast, no CALR mutations have ever been reported in the context of polycythemia vera (PV). Here, we describe 2 JAK2(V617F)-JAK2(exon12)-negative PV patients who presented with a CALR mutation in peripheral granulocyt...

Brief Report MYELOID NEOPLASIA Presence of calreticulin mutations in JAK2-negative polycythemia vera

Département d’Hématologie Biologique, Pôle Laboratoires, Centre Hospitalier Universitaire de Nancy, Nancy, France; INSERM U954, Université de Lorraine, Nancy, France; Département d’Hématologie Biologique, Pôle Biologie, Centre Hospitalier Universitaire de Dijon, Dijon, France; Département de Cytologie Clinique, Pôle Biologie, Centre Hospitalier Universitaire de Nı̂mes, Nı̂mes, France; Unité Mixte...

Detection of JAK2 exon 12 mutations in 15 patients with JAK2V617F negative polycythemia vera.

To further characterize JAK2 exon 12 mutations, we performed molecular screening in 409 patients with polycythemia vera or unclear erythrocytosis with unmutated JAK2V617. The frequency of JAK2exon12 mutations was 10/63 (15.9%) in PV but only 5/346 (1.4%) in the erythrocytosis cases. Nine different mutations including four new types (D544-L545del, H538DK539LI540S, H538-K539del, V536-F547dup) wer...

Unusual presentation of motion sickness: Case report

Introduction: Motion sickness is a normal response to real. Perceived or anticipated movement. Although the prognosis is excellent it may be incapacitating for people with an occupation that requires constant movement, such as a flight attendant, pilot, astronaut, or ship crew members. The symptoms progresses from initial dizziness to vomiting. Fortunaterly most symptoms disappear once the stim...